Built on a foundation
of science

Our on-chip technologies feature the unique capability to apply mechanical forces to living human cells derived from the body. Using this technology, chiron's main aim is to recreate the synovial joint with innovative organ-on-chip platforms.

Chips in action


Take cell samples from a human patient


Nourish the cells with nutrients and inject them into the appropriate chiron platform


Use stimuli, like mechanical forces, to recreate the cell’s natural environment, with the option of adding pharmaceutical compounds


Perform analysis on the extracted medium, or the cells from the device, to understand the experimental outcome

Our platforms

Cartilage on Chip

Mimicking the effects of walking motion

The system emulates walking-induced forces on knee cartilage cells using mechanical stimulation (compression, stretching, and shear forces). It stands out as the most human-like in-vitro cartilage model on the market, faithfully reproducing extracellular and pericellular matrix production, proteins, and more. Notably, it offers real-time cell visualization during experiments, a patented feature.

synovial-membrane on Chip

Recreating the joint’s immune response

The Synovial-membrane on Chip is a co-culture system of human synovial fibroblasts, macrophages, and endothelial cells. The design facilitates the recreation of the inflammatory activity and immune response of the knee, a crucial component for drug discovery and development. The system is available in a high-throughput, automation-friendly footprint, and, like the Cartilage-on-Chip Platform, provides real-time visualization under the microscope.

Move It: for tissue explants

Applying chiron’s patented technology to the stimulation of tissue

To complement the Cartilage-on-Chip Platform, chiron created the Move It. Instead of stimulating single cartilage cells or aggregates, the Move It was designed with larger chambers to house pieces of tissue. The tissue, taken from explanted cartilage biopsies (often called cartilage plugs or punches), is cyclically compressed, like it would be in the knee. The biopsies contain all essential cells and elements of cartilage, which makes this easy-to-use, small-footprint system an eloquent approach for studying cartilage with an on-chip platform.

If you have a specific platform in mind but can't find it here, chances are, we’re already working on it. Get in touch

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