Re-plate: the next era of
organ-on-chip technologies

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Ever wondered how much plastic is wasted in laboratories across the world every day? As scientists, we know the impact—tons of discarded plastic, burned and forgotten. That’s why we created the Re-plate; the first reusable organ-on-chip platform designed for sustainability and flexibility. With removable cartridges, you can run different experiments on the same plate, seamlessly integrating with standard lab tools.

Diving Into the Re-plate

Example Systems

The process

Sample

Take cell samples from a human patient

Nourish

Nourish the cells with nutrients and inject them into the appropriate chiron platform

Stimulate

Use stimuli, like mechanical forces, to recreate the cell’s natural environment, with the option of adding pharmaceutical compounds

Analyze

Perform analysis on the extracted medium or the cells from the sacrificed device to understand the experimental outcome

Our technologies

Multi-compression

Mimic lifelike motion—walking, peristalsis, trauma

The first of its kind, this advanced in-vitro model delivers active mechanical stimulation to 3D hydrogels embedded with human cells. The proprietary technique enables recreation of the dynamic motion of the human body, bringing unparalleled realism to scientific research and unlocking breakthroughs in biomechanics and cellular behaviour. Real-time visualization allows for the optical monitoring of cellular responses as mechanical stimuli are applied, while customizable stimulation patterns offer total control over your experiments. Effortlessly adjust frequencies, mimic physiological and hyper-physiological conditions, and scale up to 144 assessments in a single experiment. Designed for seamless integration, it ensures standardized workflows; empowering researchers to push boundaries with confidence.

3D Tissue

3D cell culture and organ on chip—simplified

Grow cells in a 3D hydrogel matrix for up to 10 days with precise nutrient delivery through two independent nutrient channels. Fully compatible with real-time imaging and standard analytical tools, it supports both single cells and complex aggregates. Each cartridge contains 8 independent units, enabling scalable, parallelized experiments. With a stable nutrient supply for up to 3 days, it simplifies long-term culture. Unlock deeper insights into biological, inflammatory, and disease responses with ease.

Multi-tissue

Multiple tissues interacting as one

Human biology is complex, requiring the interaction of multiple tissues. Our Multi-tissue Unit bridges the communication gap—linking two independent 3D cellular chambers through a common perfusion channel, combining the power of our 3D Tissue and Multi-compression units within a single device. This platform enables advanced studies on tissue-tissue interaction, biomechanical responses, drug assessment, immune recruitment, and more. With up to 72 samples running in parallel, the Multi-tissue can elevate your research and bring a new level of innovation to your laboratory.

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Advancing
Scientific Research

“chiron's cartilage-on-chip system is a great, easy-to-handle 3Rs tool to evaluate osteoarthritic cartilage tissue remodeling in a relevant manner”

Prof. Magali Cucchiarini

Saarland University Medical Center

“chiron's cartilage-on-chip system is a revolutionary tool to deep dive into the complexity of the molecular mechanisms underlying osteoarthritis”

Sonia Nasi

Principal Investigator, CHUV Hospital Switzerland

“Since the 3Rs of Replacement, Reduction, and Refinement were proposed by Russel and Birch back in 1959, there have been huge advances and innovations in the area of organ-on-chip technology. chiron's cartilage-on-chip system is a timely and revolutionary tool that allows researchers to biomimetically model the molecular and cellular mechanisms involved in articular chondrocytes in the context of osteoarthritis. This advances our scientific understanding of the disease and offers new tools for screening drugs and natural compounds. Implementation of chiron’s cartilage-on-chip system in our research allows us to add an additional and crucially important R; Responsibility.”